Publications
Group highlights
In the present study, we analyzed transcriptomes and open chromatin of alveolar macrophages (AMs), interstitial macrophages (IMs) and lung monocytes from two mouse strains. These resources reveal a striking divergence in a fundamental innate immune response pathway in AMs and establish a framework for further understanding macrophage diversity in the lung.
Sajti, E., Link, V.M., Ouyang, Z. et al. Nat Immunol 21, 221–231 (2020).
News about this study on Nature Immunology.
In this study, we found that hyperoxia-sensitive mice exhibit a distinct innate immune response compared to resilient strains. Notably, the hyperoxia-sensitive C57BL/6J strain showed selective upregulation of TREM2 on lung macrophages and monocytes. Deletion of TREM2 in myeloid cells led to reduced inflammation, preserved alveolar structure and sustained cell proliferation in the developing lung following oxygen exposure. Mechanistically, TREM2 loss limited p53 activation, favoring cell-cycle arrest over apoptosis. These results identify TREM2 as a key driver of immune-mediated lung injury in neonatal hyperoxia and suggest it may be a promising therapeutic target for preventing or treating bronchopulmonary dysplasia in vulnerable preterm infants.
Abe, Y., Spann, N.J., Tang, W. et al. Nat Immunol 26, 1287–1298 (2025).
This present study was initiated by members of the NHLBI-funded LungMAP Consortium and aided by experts in the lung biology community. We synthesized current data into a comprehensive and practical cellular census of the lung. Identities of cell types in the normal lung are captured in individual cell cards with delineation of function, markers, developmental lineages, heterogeneity, regenerative potential, disease links, and key experimental tools.
Xin Sun^, Anne-Karina Perl, Rongbo Li, Sheila M Bell, Eniko Sajti, Vladimir V Kalinichenko, Tanya V Kalin, Ravi S Misra, Hitesh Deshmukh, Geremy Clair, Jennifer Kyle, Laura E Crotty Alexander, Jorge A Masso-Silva, Joseph A Kitzmiller, Kathryn A Wikenheiser-Brokamp, Gail Deutsch, Minzhe Guo, Yina Du, Michael P Morley, Michael J Valdez, Haoze V Yu, Kang Jin, Eric E Bardes, Jarod A Zepp, Terren Neithamer, Maria C Basil, William J Zacharias, Jamie Verheyden, Randee Young, Gautam Bandyopadhyay, Sara Lin, Charles Ansong, Joshua Adkins, Nathan Salomonis, Bruce J Aronow, Yan Xu, Gloria Pryhuber, Jeff Whitsett, Edward E Morrisey^, NHLBI LungMAP Consortium.(^Corresponding author)